Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
Identifieur interne : 003960 ( Main/Exploration ); précédent : 003959; suivant : 003961Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
Auteurs : H. A Hutchison [Canada] ; R. J. Allan [Canada] ; H. Opitz [Allemagne] ; R. Levy [Canada] ; J. O. Dostrovsky [Canada] ; A. E. Lang ; A. M. LozanoSource :
- Annals of Neurology [ 0364-5134 ] ; 1998-10.
English descriptors
- KwdEn :
- Adult, Aged, Electric Stimulation, Electrodes, Implanted, Humans, Middle Aged, Neurons (physiology), Neurophysiology (methods), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Substantia Nigra (pathology), Substantia Nigra (physiopathology), Thalamic Nuclei (pathology), Thalamic Nuclei (physiopathology), Thalamic Nuclei (surgery).
- MESH :
- methods : Neurophysiology.
- pathology : Parkinson Disease, Substantia Nigra, Thalamic Nuclei.
- physiology : Neurons.
- physiopathology : Parkinson Disease, Substantia Nigra, Thalamic Nuclei.
- surgery : Parkinson Disease, Thalamic Nuclei.
- Adult, Aged, Electric Stimulation, Electrodes, Implanted, Humans, Middle Aged.
Abstract
Microelectrode recording methods for stereotactic localization of the subthalamic nucleus (STN) and surrounding structures are described. These methods accurately define targets for chronic deep brain stimulation in the treatment of Parkinson's disease. Mean firing rates and a burst index were determined for all recorded neurons, and responses to active and passive limb and orofacial movements were tested. STN neurons had a mean firing rate of 37 ± 17 Hz (n = 248) and an irregular firing pattern (median burst index, 3.3). Movement‐related activity and tremor cells were identified in the STN. Ventral to the STN, substantia nigra pars reticulata neurons had a mean rate of 71 ± 23 Hz (n = 56) and a more regular firing pattern (median burst index, 1.7). Short trains (1–2 seconds) of electrical microstimulation of STN could produce tremor arrest but were and found to be useful for localization. Compared with data from normal monkeys our findings suggest that STN neuronal activity is elevated in Parkinson's disease.
Url:
DOI: 10.1002/ana.410440407
Affiliations:
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A" last="Hutchison">H. A Hutchison</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Division of Neurosurgery, Toronto Hospital, 399 Bathurst St EW6‐528, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Allan, R J" sort="Allan, R J" uniqKey="Allan R" first="R. J." last="Allan">R. J. Allan</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Opitz, H" sort="Opitz, H" uniqKey="Opitz H" first="H." last="Opitz">H. Opitz</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Current Address: Eberhard‐Karls‐Unversität, Neurologische Klinik, Hoppe‐Seylerstr 3, D‐72076 Tübingen</wicri:regionArea><wicri:noRegion>72076 Tübingen</wicri:noRegion><wicri:noRegion>D‐72076 Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Levy, R" sort="Levy, R" uniqKey="Levy R" first="R." last="Levy">R. Levy</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J. O." last="Dostrovsky">J. O. 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Lozano</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Division)</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998-10">1998-10</date><biblScope unit="volume">44</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="622">622</biblScope><biblScope unit="page" to="628">628</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">20C6B3BF1280A63E91025B4D505AE27367DF6AAC</idno><idno type="DOI">10.1002/ana.410440407</idno><idno type="ArticleID">ANA410440407</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electric Stimulation</term><term>Electrodes, Implanted</term><term>Humans</term><term>Middle Aged</term><term>Neurons (physiology)</term><term>Neurophysiology (methods)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (physiopathology)</term><term>Thalamic Nuclei (pathology)</term><term>Thalamic Nuclei (physiopathology)</term><term>Thalamic Nuclei (surgery)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurophysiology</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electric Stimulation</term><term>Electrodes, Implanted</term><term>Humans</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microelectrode recording methods for stereotactic localization of the subthalamic nucleus (STN) and surrounding structures are described. These methods accurately define targets for chronic deep brain stimulation in the treatment of Parkinson's disease. Mean firing rates and a burst index were determined for all recorded neurons, and responses to active and passive limb and orofacial movements were tested. STN neurons had a mean firing rate of 37 ± 17 Hz (n = 248) and an irregular firing pattern (median burst index, 3.3). Movement‐related activity and tremor cells were identified in the STN. Ventral to the STN, substantia nigra pars reticulata neurons had a mean rate of 71 ± 23 Hz (n = 56) and a more regular firing pattern (median burst index, 1.7). Short trains (1–2 seconds) of electrical microstimulation of STN could produce tremor arrest but were and found to be useful for localization. Compared with data from normal monkeys our findings suggest that STN neuronal activity is elevated in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A. M." last="Lozano">A. M. Lozano</name></noCountry><country name="Canada"><noRegion><name sortKey="Hutchison, H A" sort="Hutchison, H A" uniqKey="Hutchison H" first="H. A" last="Hutchison">H. A Hutchison</name></noRegion><name sortKey="Allan, R J" sort="Allan, R J" uniqKey="Allan R" first="R. J." last="Allan">R. J. Allan</name><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J. O." last="Dostrovsky">J. O. Dostrovsky</name><name sortKey="Levy, R" sort="Levy, R" uniqKey="Levy R" first="R." last="Levy">R. Levy</name></country><country name="Allemagne"><noRegion><name sortKey="Opitz, H" sort="Opitz, H" uniqKey="Opitz H" first="H." last="Opitz">H. Opitz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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